Heart expression @MPI Bad Nauheim
 
 

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Microarray expression dataset: regenerative response of newt hearts to mechanical injury.

We included a series of time-points into our gene expression that represent critical stages in the regenerative process.
All time-points were investigated with at least 4 individual biological samples, that were technically replicated by dye
swap experiments (n=8).

The time-course including the following stages.

Sham operated: General stress responses due to anaesthesia and opening of the thorax.
2 hours post injury: Downstream effectors of immediate early response.
6 hours post injury: First signals of inflammatory cell recruitment and inititation of cell death.
24 hours post injury: Infiltration of inflammatory cell types and early signs of deprogramming.
48 hours post injury: Cellular deprogramming and re-entry into cell cylce.
4 days post injury: Transition between dedifferentiation and proliferation.
7 days post injury: Increase in proliferative activity of Cardiomocytes.
14 days post injury: Increase in proliferative activity of Cardiomocytes.
21 days post injury: Increase in extracellular matrix depostion.
35 days post injury: Transition from proliferation to ventricular reconstruction.