Expression Search Heart
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This form allows a expression search for single or multipe time-points in newt heart regeneration. There are two ways to define the fold change threshold(s) for a single timepoint. On the hand, a log-fc threshold can be defined by choosing from the dropdown, whether to search for ests above, below or equal to this threshold. On the other hand, the dropdown allows the option to search for a expression range. A range can be defined by a input of two log-numbers divided by one the range separators which are dash(-), comma (,), semicolon(;) or slash (/). Furthermore you need to define a pValue threshold (like 0.05). The default decimal separator is a point(.).
The global operator allows to define, whether the single queries should be conjuncted (AND) or disjuncted (OR).
Microarray expression dataset: regenerative response of newt hearts to mechanical injury.We included a series of time-points into our gene expression that represent critical stages in the regenerative process.
All time-points were investigated with at least 4 individual biological samples, that were technically replicated by dye
swap experiments (n=8).
The time-course including the following stages.
|Sham operated:||General stress responses due to anaesthesia and opening of the thorax.|
|2 hours post injury:||Downstream effectors of immediate early response.|
|6 hours post injury:||First signals of inflammatory cell recruitment and inititation of cell death.|
|24 hours post injury:||Infiltration of inflammatory cell types and early signs of deprogramming.|
|48 hours post injury:||Cellular deprogramming and re-entry into cell cylce.|
|4 days post injury:||Transition between dedifferentiation and proliferation.|
|7 days post injury:||Increase in proliferative activity of Cardiomocytes.|
|14 days post injury:||Increase in proliferative activity of Cardiomocytes.|
|21 days post injury:||Increase in extracellular matrix depostion.|
|35 days post injury:||Transition from proliferation to ventricular reconstruction.|